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Area for PENTA network members (password
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ESPID/PENTA training program Since 2005 PENTA in collaboration with ESPID has run on-line and residential courses for health careworkers caring for HIV infected children in Europe. The first courses for healthcare workers in Africa will begin in 2007.
New collaborations
PENTA together with the CASCADE, Eurosida and EuropeHIVResistance groups
has received funding from the European Commission for the ACTIVATE project
which will provide capacity building and training for health care workers.
PENTA is also a partner in the NEAT network of excellence; this will help establish a clinical and laboratory network for enrolling adolescents in clinical trials.
Withdrawal of PCP prophylaxis
Some PENTA clinical centres conducted a retrospective analysis of withdrawal of PCP prophylaxis. The analysis has been published in AIDS:
Urschel S, Ramos J, Mellado M, Giaquinto C, Verweel G,
Schuster T, Niehues T, Belohradsky B, Wintergerst U; the European PCP-withdrawal
Study Group. Withdrawal of Pneumocystis jirovecii prophylaxis in HIV-infected
children under highly active antiretroviral therapy. AIDS. 2005
Dec 2;19(18):2103-2108. (Reference)
HPPMCS Collaboration
PENTA has contributed data to The HIV Paediatric Prognostic Markers Collaborative Study (HPPMCS), an individual-patient-data meta-analysis to investigate the "natural history" of HIV-1 RNA and CD4+ cell count in perinatally HIV-infected children. This was a collaboration of investigators of European and American cohort studies and randomised trials of ART or immune therapies in HIV-infected children and has data on more than 5000 children exposed to either no treatment or zidovudine monotherapy only. This study has developed a risk calculator which gives estimates of the short-term risks of progression to AIDS and death in the absence of therapy.