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The Paediatric European Network for the treatment of AIDS (PENTA) was established in 1991 as a collaboration between paediatric HIV centres in Europe. The trials are co-ordinated by the HIV Division of MRC Clinical Trials Unit , London and ANRS, INSERM SC10, Paris and PHPT in Chiang Mai, Thailand for some trials. Certain trials are run in collaboration with the NICHD and IMPAACT in the USA.

The PENTA Steering Committee, chaired by Dr Carlo Giaquinto from Italy, includes representatives from all participating European countries. A core Executive committee co-opts specialists where appropriate for the co-ordination of an individual trial. Virology, immunology and pharmacokinetic committees advise the Steering Committee and plans protocol substudies.

PENTA trials are principally funded by the EU through BIOMED II, by governmental and regional bodies in France, Italy, Spain and the UK. Support from the pharmaceutical and biotechnology companies for individual trials.

Objectives

  • Address questions about treatment for children with HIV which cannot be answered in adults principally because:
    • natural history of vertical HIV infection differs
    • tolerance of drugs may be different
  • Collaboration with adult trials networks and PACTG
  • evaluate primarily safety and tolerability in children to parallel efficacy trials in adults

PENTA Executive Committee

Jean-Pierre Aboulker, INSERM SC10, Paris
Abdel Babiker, MRC Clinical Trials Unit, London
David Burger, Radboud University Medical Center Nijmegen
Alexandra Compagnucci, INSERM SC10, Paris
Janet Darbyshire, MRC Clinical Trials Unit
Carlo Giaquinto, Università di Padova
Diana Gibb, MRC Clinical Trials Unit, London
Hannah Green, MRC Clinical Trials Unit, London
Nigel Klein, Insitute of Child Health, London
Hermione Lyall, St Marys' Hospital, London
Deenan Pillay, University College London
Yacine Saïdi, INSERM SC10, Paris


PENTA Steering Committee

Paediatricians and Specialists in Infectious Diseases:
  • Argentina: Rosa Bologna
  • Belgium: Jack Levy
  • Brazil: Marinella Della Negra
  • Denmark: Nils Valerius
  • France: Albert Faye
  • Germany: Ilse Grosch-Wörner, Tim Nieheus
  • Ireland, Karina Butler
  • Italy: Carlo Giaquinto (Chair), Pier Angelo Tovo, Stefania Bernardi, Raffaella Rosso
  • Netherlands: Henriette Scherpbier, Ronald De Groot
  • Poland: Magdalena Marczynska
  • Portugal:
  • Romania: Don Duiculescu, Martina Mardarescu
  • Spain: Maria-José Mellado Pena, José Tomas Ramos Amador
  • Sweden: Eric Belfrage
  • Switzerland: David Nadal, Christoph Rudin
  • Thailand: Jintanat Ananworanich
  • UK: Mike Sharland, Steve Welch, Catherine Peckham

Training

  • Hermione Lyall, UK
  • Guido Castelli-Gattinara, Italy

Community Representatives

  • Polly Clayden, i-base, UK
  • Milena Stevanovic, Solidarité Enfants Sida European Aids Treatment Group (EATG), Macedonia

Co-ordinating Trials Centres:

For trials:

  • PENPACT 1: Gareth Tudor-Willams, London
  • PENTA 17: Uwe Wintergerst, Braunau

ECS link:

  • Claire Thorne, ICH, London

Data and Safety Monitoring Committee

  • Catherine Hill (Chair), Statistician, Institut Gustave Roussy, Paris, France
  • Anton Pozniak, GU Physician, Chelsea and Westminster Hospital, London, UK
  • Stefano Vella, Istituto Superiore di Sanità, Roma, Italy
  • Philippe Lepage, Professor of Paediatrics, University of Liège, Belgium

Virology/Immunology Committee

  • Anita De Rossi, Padova, Italy
  • Nigel Klein, London, UK
  • Maria Muñoz Fernandez, Madrid, Spain
  • Nicole Ngo, Chiang Mai, Thailand
  • Deenan Pillay, London, UK

Pharmacology Committee

  • Evelyne Jacqz-Aigrain, Paris, France
  • David Burger, Nijmegen, the Netherlands
  • Tim Cressey, Chiang Mai, Thailand
  • Saye Khoo, Liverpool, UK
  • Mario Regazzi, Pavia, Italy
  • Jean Marc Tréluyer, Paris, France

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Updated 8 July, 2009