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The Paediatric European Network for the treatment of AIDS (PENTA) was established in 1991 as a collaboration between paediatric HIV centres in Europe. The trials are co-ordinated by the HIV Division of MRC Clinical Trials Unit , London and ANRS, INSERM SC10, Paris and PHPT in Chiang Mai, Thailand for some trials. Certain trials are run in collaboration with the NICHD and IMPAACT in the USA.

The PENTA Steering Committee, chaired by Dr Carlo Giaquinto from Italy, includes representatives from all participating European countries. A core Executive committee co-opts specialists where appropriate for the co-ordination of an individual trial. Virology, immunology and pharmacokinetic committees advise the Steering Committee and plans protocol substudies.

PENTA trials are principally funded by the EU through BIOMED II, by governmental and regional bodies in France, Italy, Spain and the UK. Support from the pharmaceutical and biotechnology companies for individual trials.

Objectives

• Address questions about treatment for children with HIV which cannot be answered in adults principally because:
  • natural history of vertical HIV infection differs
  • tolerance of drugs may be different
• Collaboration with adult trials networks and PACTG
• evaluate primarily safety and tolerability in children to parallel efficacy trials in adults

PENTA Executive Committee

Jean-Pierre Aboulker, INSERM SC10, Paris
Abdel Babiker, MRC Clinical Trials Unit, London
Alexandra Compagnucci, INSERM SC10, Paris
Janet Darbyshire, MRC Clinical Trials Unit
Marianne Debré, Hôpital Necker, Paris
Carlo Giaquinto, Università di Padova
Diana Gibb, MRC Clinical Trials Unit, London

PENTA Steering Committee

• Belgium: Jack Levy
• Brazil: Marinella Della Negra
• Denmark: Nils Valerius
• Eire: Karina Butler
• France: Marianne Debré, Albert Faye
• Germany: Ilse Grosch-Wörner, Uwe Wintergerst, Tim Nieheus
• Italy: Guido Castelli-Gattinara, Carlo Giaquinto (Chair), Pier Angelo Tovo
• Netherlands: Henriette Scherpbier, Ronald De Groot
• Poland: Magdalena Marczynska
• Portugal: Lino Rosado
• Romania: Don Duiculescu
• Spain: Maria-José Mellado Pena, José Tomas Ramos Amador
• Sweden: Ann-Britt Bohlin
• Switzerland: David Nadal, Christoph Rudin
• UK: Hermione Lyall, Catherine Peckham, Mike Sharland, G Tudor-Williams

Community Representatives

• Polly Clayden, i-base, UK
• Milena Stevanovic, Solidarité Enfants Sida European Aids Treatment Group (EATG), Macedonia

Co-ordinating Trials Centres:

• INSERM SC10: Jean-Pierre Aboulker, Alex Campagnucci

• MRC Clinical Trials Unit: Abdel Babiker, Janet Darbyshire, Di Gibb, Sarah Walker

• PHPT: Marc Lallemant

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Data and Safety Monitoring Committee

Catherine Hill (Chair), Statistician, Institut Gustave Roussy, Paris, France
Philippe Lepage, Professor of Paediatrics, University of Liège, Belgium
Anton Pozniak, GU Physician, Chelsea and Westminster Hospital, London, UK
Stefano Vella, Istituto Superiore di Sanità, Roma, Italy

Virology/Immunology Committee

Pharmacology Committee

Evelyne Jacqz-Aigrain, Paris, France
Giorgio Gatti, Genova, Italy
David Burger, Nijmegen, the Netherlands
Saye Khoo, Liverpool, UK
Jean Marc Tréluyer, Paris, France
Polly Clayden, London, UK

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