was established in 1991 as a collaboration between paediatric HIV centres in Europe. Trials are principally funded by the European Union through BIOMED II, by governmental bodies in a number of European countries and by support from the pharmaceutical industry.

The PENTA foundation for the treatment and care of children with HIV serves as an umbrella for the PENTA clinical trials network as well as for future work in training and cohort collaborations.

Many questions about treatment for HIV can be answered in adult trials and it is unnecessary to repeat all trials in children. However, the natural history of vertical HIV infection differs from that in adults in some important ways and the tolerance of drugs in children may also be different.

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Updated 23 April, 2008

PENTA 11 substudy is published in CID

"Plasma drug concentrations and virologic evaluations after stopping treatment with non-nucleoside reverse-transcriptase inhibitors in HIV type 1-infected children" Clin Infect Dis. 2008 May 15;46(10):1601-8

Tr@inforPedHIV - 2008 ESPID/PENTA training program for healthcare workers caring for HIV-infected children

Registration is now open for the 2008 online and residential courses (Rome, 22-24 October 2008).
Click here for the first announcement and a flyer

Further information on planned courses for Africa and Central America can be found here soon.

ACTIVATE COURSE ON HIV MANAGEMENT

The 2nd International ACTIVATE HIV Course: 8th - 9th November, Glasgow 2008 This exciting clinical training course is part of the ACTIVATE initiative and precedes the Ninth International Congress on Drug Therapy in HIV Infection. Clinicians from central and eastern Europe are particularly encouraged to participate. The course is aimed at doctors and pharmacists, either practicing or in-training. Click here for more information and how to register

PENTA 15, PENTA 11 and PENPACT 1 have been adopted by the UK Medicines for Children Research Network. The MCRN website (www.mcrn.org.uk) gives information on the local research networks and the training courses now available.

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