was established in 1991 as a collaboration between paediatric HIV centres in Europe. Trials are principally funded by the European Commission*, by governmental bodies in a number of European countries and by support from the pharmaceutical industry.
The PENTA foundation for the treatment and care of children
with HIV serves as an umbrella for the PENTA clinical trials network as
well as for future work in training and cohort collaborations.
Many questions about treatment for HIV can be answered
in adult trials and it is unnecessary to repeat all trials in children.
However, the natural history of vertical HIV infection differs from that
in adults in some important ways and the tolerance of drugs in children
may also be different.
A training programme for health care workers caring for HIV infected children,
using a methodology integrating distance learning with an interactive residential
course. Registration is now open. For more details please go to the training
page.
BREATHER
Trial Recruitment Continues
The BREATHER
(PENTA 16) trial, which will evaluate the strategy of Short
Cycle Therapy (SCT), five days on ART and two days off, is now recruiting
to the main study.
The IDMC reviewed the pilot study data and raised no safety concerns and recommended
that recruitment continues.The trial is now open to recruitment in Argentina,
Denmark, Ireland, Spain, Thailand, Uganda, UK, the Ukraine and the USA with further countries
opening shortly.
A protocol amendment has been submitted to extend recruitment to ages
8 - 24 (currently young people between the ages of 8
and
21are eligible). Clinicians interested in enrolling should
contact a Trials Unit.
KONCERT Trial Recruited
The KONCERT
(PENTA 18) is evaluating whether once-daily Kaletra is as safe and
effective as twice daily dosing. Participants from Europe, Thailand and South
America are currently taking part in this study which is now closed to recruitment.
All participants will be followed until July 2013.
Vaccination Guidance
The PENTA and CHIVA guidance on the vaccination of HIV-infected children in Europe has been published in HIV Medicine
Collaboration with EuroCoord
PENTA is one of four projects now collaborating in EuroCoord – a
European network of HIV/AIDS cohort studies to coordinate clinical research
on HIV/AIDS at European and International levels. This initiative of
the CASCADE, COHERE, EuroSIDA and PENTA projects has been funded by the
EU seventh Framework Program.
*DISCLAIMER: The project has received funding from the European Commission under the Public Health Programme 2003-2008. However, the sole responsibility for the study lies with the author and the European Commission is not responsible for any use that may be made of the information contained therein.
was established in 1991 as a collaboration between paediatric HIV centres in Europe. Trials are principally funded by the European Commission*, by governmental bodies in a number of European countries and by support from the pharmaceutical industry.
*DISCLAIMER: The project has received funding from the European Commission under the Public Health Programme 2003-2008. However, the sole responsibility for the study lies with the author and the European Commission is not responsible for any use that may be made of the information contained therein.