was established in 1991 as a collaboration between paediatric HIV centres in Europe. Trials are principally funded by the European Commission, by governmental bodies in a number of European countries and by support from the pharmaceutical industry.

The PENTA foundation for the treatment and care of children with HIV serves as an umbrella for the PENTA clinical trials network as well as for future work in training and cohort collaborations.

Many questions about treatment for HIV can be answered in adult trials and it is unnecessary to repeat all trials in children. However, the natural history of vertical HIV infection differs from that in adults in some important ways and the tolerance of drugs in children may also be different.

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Updated 23 July, 2010

 

Presentation of PENPACT 1 Results at Paediatric Workshop and International AIDS Conference in Vienna, Austria

An oral presentation of the results of the PENPACT 1 trial was given at the 2nd International workshop on HIV Pediatrics in Vienna on Friday the 16th July and at the XVIII International AIDS Conference in Vienna on Thursday 22nd July. Click here for further details and to view slides of the presentation.

New PENTA trials

2 new PENTA trials have been granted ethical approval in the the UK and are currently being submitted for ethical and regulatory review internationally. BREATHER (PENTA 16) aims to evaluate whether Short Cycle Therapy (5 days on, 2 days off) can maintain viral suppression. KONCERT (PENTA 18) will evaluate whether once daily dosing of Kaletra is as effective as twice daily dosing. Clinicians interested in enrolling children should contact a Trials Unit.

Tr@inforPedHIV training course 2010

The PENTA/ESPID 2010 training programme for health care workers caring for HIV infected children is now open. The course uses a methodology integrating distance learning with an interactive residential course in Rome in October 2010. For more details please go to the training page.

Paediatric Guidelines

The 2009 PENTA Guidelines for the use of antiretroviral therapy in paediatric HIV infection have been published in HIV Medicine. PENTA has drafted a letter about the updated WHO paediatric guidelines 2010 (presented in Vienna). Please send any comments on the letter to PENTA via e-mail.

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