was established in 1991 as a collaboration between paediatric HIV centres in Europe. Trials are principally funded by the European Commission*, by governmental bodies in a number of European countries and by support from the pharmaceutical industry.

The PENTA foundation for the treatment and care of children with HIV serves as an umbrella for the PENTA clinical trials network as well as for future work in training and cohort collaborations.

Many questions about treatment for HIV can be answered in adult trials and it is unnecessary to repeat all trials in children. However, the natural history of vertical HIV infection differs from that in adults in some important ways and the tolerance of drugs in children may also be different.

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Updated 29 February, 2012

 

Tr@inforPedHIV training course 2012

A training programme for health care workers caring for HIV infected children, using a methodology integrating distance learning with an interactive residential course. Registration is now open. For more details please go to the training page.

BREATHER Trial Begins Recruiting to the Main Study

The BREATHER (PENTA 16) trial, which will evaluate the strategy of Short Cycle Therapy (SCT), five days on ART and two days off, is now recruiting to the main study. The IDMC reviewed the pilot study data and raised no safety concerns and recommended that recruitment continues.Clinicians interested in enrolling young people between the ages of 8 and 21 should contact a Trials Unit.

KONCERT Trial Currently Recruiting

The KONCERT (PENTA 18) evaluates whether once-daily Kaletra is as safe and effective as twice daily dosing. Participants from Europe and Thailand are currently taking part in this study which is still open to recruitment. If you have patients that you would like to include in this study please contact your Trials Unit.

Collaboration with EuroCoord

PENTA is one of four projects now collaborating in EuroCoord – a European network of HIV/AIDS cohort studies to coordinate clinical research on HIV/AIDS at European and International levels. This initiative of the CASCADE, COHERE, EuroSIDA and PENTA projects has been funded by the EU seventh Framework Program.

*DISCLAIMER: The project has received funding from the European Commission under the Public Health Programme 2003-2008. However, the sole responsibility for the study lies with the author and the European Commission is not responsible for any use that may be made of the information contained therein.

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